One year ago, the San Francisco Giants thought they had finally bought their way out of a long-standing lineup issue. After whiffing over the years on Giancarlo Stanton, Bryce Harper, Aaron Judge and Shohei Ohtani, the Giants finally landed the kind of superstar bat they had been chasing for years. One year after the Rafael...

Find out why From fans are so intrigued by The Man in Yellow.

A detailed cellular study of Crohn's disease has mapped how gene activity changes across more than 50 cell types in the gut. The study provides an open resource of the genes that characterize each cell type and those whose activity shifts in disease, uncovering new molecular and cellular signatures of immune activity in the gut lining.

It was a record-setting day along the Oregon coast over the weekend.

The Colonel is making major changes to its menus, branding and restaurant design worldwide. Here’s what’s new: Dipped: Crispy tenders and other boneless items paired with sauces from KFC’s new global “pantry,” which includes more than 20 sauces ranging from modern takes on classics to internationally inspired flavors. Markets can tailor offerings to local tastes, [...]

“The order volumes for the Knicks is something we have not seen for any other sport or team,” said Sam Archibald, head of merchandising for Fanatics.

Long before massive steel coasters launched riders into physics-defying drops and corkscrews, Pennsylvania helped define the art of the wooden roller coaster. When they debuted in the early 20th century, many of the state’s classic amusement parks drew city dwellers to lakesides, river valleys, and wooded hillsides for fresh air and excitement. By the 1920s, innovative coaster engineers at local firms like the Philadelphia Toboggan Company were transforming timber into gravity-powered marvels that hugged ravines, climbed hills, and delivered stomach-dropping airtime. A true testament to their design and appeal, some of these iconic rides continue to thrill riders today. For those wanting to trace the evolution of the wooden coaster—from some of the oldest operating rides on Earth to modern creations inspired by their predecessors—Pennsylvania is one of the best places to experience every incredible curve, climb, and drop. Jack RabbitKennywood Amusement Park, West Mifflin One of the ol

A young boy drowned during a World Cup watch party in El Segundo on Friday. He was identified in a GoFundMe as Taylor Thach, a student at Central Street School. The fundraiser also confirmed he passed away “following an accidental drowning.” “He was known for his kind heart and friendly spirit,” the fundraiser reads. “Affectionate and polite, he [...]

Human immunodeficiency virus 1 (HIV-1) detection in wastewater offers a novel approach to monitor the virus in communities. Baylor College of Medicine researchers and colleagues at collaborating institutions report in Nature Communications that their method, called hybrid-capture genetic sequencing, allows them to analyze viral genomes in detail and specifically identify viral signals coming from community wastewater.

Dual-target CAR T-cell therapy for recurrent glioblastoma (GBM), delivered directly into the cerebrospinal fluid (CSF), triggers a broad immune response, with natural killer (NK) cell activation linked to better patient outcomes and longer overall survival. CSF of individuals who did not respond to the therapy exhibited a higher proportion of activated regulatory T cells (Tregs) and high baseline levels of immunosuppressive scavenger myeloid cells, according to new research from the Perelman School of Medicine and Abramson Cancer Center at the University of Pennsylvania, published in Cell.

Caltech researchers have identified a novel chemical reaction that could explain the formation of the building blocks of DNA and RNA, the molecules that encode all of life's functions. The work is an important step toward understanding how life may have emerged on Earth and potentially elsewhere in the universe, showing the straightforward and efficient pathways through which simple molecules can give rise to complex biological precursors.